Background: Hypertension is a risk factor for peripheral arterial disease (PAD). Subjects with PAD are at increased\nrisk of future cardiovascular (CV) events. Resistin is involved in the pathological processes of CV diseases. The aim of\nthis study is to investigate whether resistin level is correlated with PAD in hypertensive patients.\nMethods: One hundred and twenty-four hypertensive patients were enrolled in this study. Ankle-brachial index\n(ABI) values were measured using the automated oscillometric method. An ABI value < 0.9 defined the low ABI\ngroup. Anthropometric analysis with waist circumference and body mass index, and fasting serum levels of blood\nurea nitrogen, creatinine, glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density\nlipoprotein cholesterol, total calcium, phosphorus, and high-sensitivity C-reactive protein (hs-CRP) were measured\nusing standard enzymatic automated methods. Serum levels of human resistin were determined using a commercially\navailable enzyme immunoassay.\nResults: Eighteen hypertensive patients (14.5%) were included in the low ABI group. Hypertensive patients in\nthe low ABI group were older (p = 0.043) and had higher serum creatinine (p < 0.001), high-sensitivity C-reactive\nprotein (hs-CRP; p = 0.013), and resistin (p < 0.001) levels but a lower estimated glomerular filtration rate (p = 0.002)\nthan patients in the normal ABI group. After the adjustment for factors that were significantly associated with PAD on\nmultivariate logistic regression analysis, serum resistin (odds ratio [OR], 1.176; 95% confidence interval [CI], 1.028ââ?¬â??1.345;\np = 0.018) was also an independent predictor of PAD in hypertensive patients.\nConclusions: A high serum resistin level is an independent predictor of PAD in hypertensive patients.
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